IMAGE | GO ID | PDB ID | DESCRIPTION | DEPOSITION | RELEASED | PUBMED ID |
---|---|---|---|---|---|---|
GO.119373 | 2LUZ | Solution NMR Structure of CalU16 from Micromonospora echinospora, Northeast Structural Genomics Consortium (NESG) Target MiR12 |
2012-06-22 | 2012-10-03 | PMID:25079510 | |
GO.119399 | 3IA7 | Crystal structure of CalG4, the calicheamicin glycosyltransferase |
2009-07-13 | 2010-06-02 | PMID:21987796 | |
GO.119382 | 3IAA | Crystal structure of CalG2, calicheamicin glycosyltransferase, TDP bound form |
2009-07-13 | 2010-06-02 | PMID:21987796 | |
GO.119370 | 3OTG | Crystal structure of CalG1, calicheamicin glycosyltransferase, TDP bound form |
2010-09-11 | 2010-12-15 | PMID:21987796 | |
GO.119370 | 3OTH | Crystal structure of CalG1, calicheamicin glycosyltransferase, TDP and calicheamicin alpha3I bound form |
2010-09-11 | 2010-12-15 | PMID:21987796 | |
GO.119385 | 3OTI | Crystal structure of CalG3, calicheamicin glycosyltransferase, TDP and calicheamicin T0 bound form |
2010-09-11 | 2010-12-15 | PMID:21987796 | |
GO.119382 | 3RSC | Crystal structure of CalG2, calicheamicin glycosyltransferase, TDP and calicheamicin T0 bound form |
2011-05-02 | 2011-08-10 | PMID:21987796 | |
GO.111124 | 3TOS | Crystal structure of CalS11, calicheamicin methyltransferase |
2011-09-06 | 2011-10-05 | PMID:23662776 | |
GO.119373 | 4FPW | Crystal structure of CalU16 from Micromonospora echinospora |
2012-06-22 | 2012-12-12 | PMID:25079510 | |
GO.120792 | 4FZR | Crystal structure of SsfS6, Streptomyces sp. SF2575 glycosyltransferase |
2012-07-07 | 2012-07-25 | PMID:23526584 | |
GO.120792 | 4G2T | Crystal structure of Streptomyces sp. SF2575 glycosyltransferase SsfS6, complexed with thymidine diphosphate |
2012-07-12 | 2012-07-25 | PMID:23526584 | |
GO.111124 | 4GF5 | Crystal structure of calicheamicin methyltransferase, CalS11 |
2012-08-02 | 2012-08-22 | PMID:23662776 | |
GO.119311 | 4HPV | Crystal structure of S-adenosylmethionine synthetase from Sulfolobus solfataricus 98/2 |
2012-10-24 | 2012-11-14 | PMID:24649856 | |
GO.119753 | 4HVM | Crystal structure of tallysomycin biosynthesis protein TlmII |
2012-11-06 | 2012-11-21 | ||
GO.119605 | 4HX6 | The crystal structure of an oxidoreductase (SgcE6) from Streptomyces globisporus |
2012-11-09 | 2012-11-28 | PMID:27560143 | |
GO.120959 | 4HZN | The Structure of the bifunctional acetyltransferase/Decarboxylase LnmK from the Leinamycin biosynthetic pathway revealing novel activity for a double hot dog fold |
2012-11-15 | 2013-01-30 | PMID:23320975 | |
GO.120959 | 4HZO | The structure of the bifunctional acetyltransferase/decarboxylase LnmK from the Leinamycin biosynthetic pathway revealing novel activity for a double hot dog fold |
2012-11-15 | 2013-01-30 | PMID:23320975 | |
GO.120959 | 4HZP | The structure of the fifunctional acetyltransferase/decarboxylase LnmK from the Leinamycin biosynthetic pathway revealing novel activity for a double hot dog fold |
2012-11-15 | 2013-01-30 | PMID:23320975 | |
GO.119385 | 4I19 | The crystal structure of an epoxide hydrolasen from Streptomyces carzinostaticus subsp. neocarzinostaticus |
2012-11-20 | 2012-12-05 | ||
GO.119869 | 4MV2 | Crystal structure of plu4264 protein from Photorhabdus luminescens |
2012-11-27 | 2012-12-05 | PMID:25354690 | |
GO.119729 | 4NEO | Structure of BlmI, a type-II acyl-carrier-protein from Streptomyces verticillus involved in bleomycin biosynthesis |
2013-10-29 | 2014-01-29 | PMID:25050442 | |
GO.119599 | 4I4J | The structure of SgcE10, the ACP-polyene thioesterase involved in C-1027 biosynthesis |
2013-01-06 | 2013-03-20 | ||
GO.119584 | 4I4K | Crystal structure of conserved uncharacterized protein SgcJ from Streptomyces globisporus |
2012-11-27 | 2012-12-12 | PMID:27406907 | |
GO.119782 | 4IAG | Crystal structure of ZbmA, the zorbamycin binding protein from Streptomyces flavoviridis |
2012-12-06 | 2013-02-20 | PMID:26512730 | |
GO.120791 | 4K0B | Crystal structure of S-Adenosylmethionine synthetase from Sulfolobus solfataricus 98/2 complexed with SAM and PPi |
2013-04-03 | 2013-05-01 | PMID:24649856 | |
GO.120791 | 4L7I | Crystal structure of S-Adenosylmethionine synthase from Sulfolobus solfataricus complexed with SAM and PPi |
2013-06-13 | 2013-07-03 | PMID:24649856 | |
GO.120791 | 4L2Z | Crystal structure of S-Adenosylmethionine synthetase from Sulfolobus solfataricus complexed with SAE and PPi |
2013-06-05 | 2013-06-19 | PMID:24649856 | |
GO.123267 | 4M60 | Crystal structure of macrolide glycosyltransferase OleD |
2013-08-08 | 2013-09-04 | ||
GO.123267 | 4M7P | Ensemble refinement of protein crystal structure of macrolide glycosyltransferases OleD |
2013-08-12 | 2013-09-11 | ||
GO.123267 | 4M83 | Ensemble refinement of protein crystal structure (2IYF) of macrolide glycosyltransferases OleD complexed with UDP and Erythromycin A |
2013-08-12 | 2013-09-11 | ||
GO.120954 | 4NNQ | Crystal structure of LnmF protein from Streptomyces amphibiosporus |
2013-11-18 | 2013-01-15 | ||
GO.119582 | 4OO2 | Crystal structure of apo-form of SgcC protein: an HpaB-family monooxygenase from Streptomyces globisporus |
2014-01-29 | 2014-02-12 | PMID:27560143 | |
GO.120998 | 4OPE | Beta-ketoacyl synthase domain (4221-4804) of polyketide synthase from Streptomyces albus |
2014-02-05 | 2014-02-19 | PMID:26420866 | |
GO.120998 | 4OPF | Beta-ketoacyl synthase domain (6118-6552) of polyketide synthase from Streptomyces albus |
2014-02-05 | 2014-02-19 | PMID:26420866 | |
GO.121006 | 4OQJ | Crystal structure of polyketide synthases from Streptomyces albus |
2014-02-09 | 2014-03-19 | PMID:26420866 | |
GO.119825 | 4OVM | Crystal structure of SgcJ protein from Streptomyces carzinostaticus |
2013-11-20 | 2013-12-25 | PMID:27406907 | |
GO.119869 | 4Q29 | Ensemble Refinement of plu4264 protein from Photorhabdus luminescens |
2014-04-07 | 2014-05-7 | PMID:25354690 | |
GO.119385 | 4QA9 | Ensemble Refinement of an epoxide hydrolase from Streptomyces carzinostaticus subsp. neocarzinostaticus |
2014-05-02 | 2014-05-21 | ||
GO.119359 | 4Q31 | The crystal structure of cystathione gamma lyase (CalE6) fromMicromonospora echinospora |
2014-04-10 | 2014-05-07 | PMID:27191010 | |
GO.111124 | 4PWR | Apo structure of CalS11, TDP-rhamnose 3-o-methyltransferase, an enzyme in Calicheamicin biosynthesis |
2014-03-21 | 2014-06-11 | ||
GO.121602 | 4TKT | Crystal structure of ketosynthase domain from MgsF protein from Streptomyces platensis |
2014-05-27 | 2014-06-11 | PMID:26420866 | |
GO.121602 | 4TL2 | Crystal structure of ketosynthase domain from MgsF from Streptomyces platensis |
2014-05-28 | 2014-06-11 | ||
GO.120448 | 4PIW | Crystal structure of sugar aminotransferase WecE from Escherichia coli K-12 |
2014-05-09 | 2014-07-16 | ||
GO.121610 | 4QYR | Crystal Structure of MgsE (2542-3153) of AT-less Polyketide Synthase from Streptomyces platensis |
2014-07-25 | 2014-08-20 | PMID:26420866 | |
GO.119366 | 4WB1 | Crystal structure of cals8 from Micromonospora Echinospora (P294S mutant) |
2014-09-02 | 2014-09-17 | ||
GO.120448 | 4WFP | Crystal structure of sugar aminotransferase WecE with External Aldimine VII from Escherichia coli K-12 |
2014-09-17 | 2014-09-24 | ||
GO.121510 | 4RD7 | The crystal structure of a Cupin 2 conserved barrel domain protein from Salinispora arenicola CNS-205 |
2014-09-18 | 2014-10-01 | ||
GO.119605 | 4R82 | The crystal structure of an oxidoreductase (SgcE6) from Streptomyces globisporus in complex with FAD and NAD |
2014-08-29 | 2014-10-01 | PMID:27560143 | |
GO. | 4RNL | The crystal structure of a possible galactose mutarotase from Streptomyces platensis subsp. rosaceus |
2014-10-24 | 2014-11-26 | ||
GO.119440 | 4XAU | Crystal structure of AtS13 from Actinomadura melliaura |
2014-12-15 | 2014-12-24 | PMID:26061967 | |
GO.119366 | 4XRR | Crystal structure of CalS8 from Micromonospora echinospora(P294S mutant) |
2015-01-21 | 2014-02-11 | PMID:26240141 | |
GO.119366 | 4XR9 | Crystal structure of CalS8 from Micromonospora echinospora cocrystallized with NAD and TDP-glucose |
2015-01-20 | 2014-02-11 | PMID:26240141 | |
GO.111134 | 4XQ2 | Ensemble refinement of cystathione gamma lyase (CalE6) D7G from Micromonospora echinospora |
2015-01-18 | 2015-04-15 | ||
GO.120448 | 4ZAH | Crystal structure of sugar aminotransferase WecE with External Aldimine VII from Escherichia coli K-12 |
2015-04-13 | 2015-04-29 | PMID:26023720 | |
GO.119384 | 4ZAS | Crystal structure of sugar aminotransferase CalS13 from Micromonospora echinospora |
2015-04-14 | 2015-04-29 | ||
GO.121602 | 4ZDN | Crystal structure of ketosynthase domain from MGSF from Streptomyces platensis |
2015-04-17 | 2015-05-13 | PMID:26420866 | |
GO.119586 | 4ZNM | Crystal structure of SgcC5 protein from Streptomyces globisporus (apo form) |
2015-05-04 | 2015-05-27 | ||
GO.119440 | 4ZWV | Crystal Structure of Aminotransferase AtmS13 from Actinomadura melliaura |
2015-05-19 | 2015-06-03 | PMID:26061967 | |
GO.119586 | 4ZXW | Crystal structure of SgcC5 protein from Streptomyces globisporus (complex with (R)-(-)-1-(2-naphthyl)-1,2-ethanediol and sucrose) |
2015-05-20 | 2015-06-17 | ||
GO.120972 | 5BMO | LnmX protein, a putative GlcNAc-PI de-N-acetylase from Streptomyces atroolivaceus |
2015-05-22 | 2015-06-10 | ||
GO.xxxxxx | 5BP8 | ent-Copalyl diphosphate synthase from Streptomyces platensis |
2015-05-27 | 2015-06-10 | PMID:27490479 | |
GO.119782 | 5CJ3 | Crystal structure of the zorbamycin binding protein (ZbmA) from Streptomyces flavoviridis with zorbamycin |
2015-07-13 | 2015-07-22 | PMID:26512730 | |
GO.120949 | 4Z5P | Crystal structure of the LnmA cytochrome P450 hydroxylase from the leinamycin biosynthetic pathway of Streptomyces atroolivaceus S-140 at 1.9 A resolution |
2015-04-02 | 2015-07-29 | ||
GO.120974 | 4Z5Q | Crystal structure of the LnmZ cytochrome P450 hydroxylase from the leinamycin biosynthetic pathway of Streptomyces atroolivaceus S-140 at 1.8 A resolution |
2015-04-02 | 2015-08-12 | ||
GO.121003 | 4WKY | Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmN KS2 |
2014-10-03 | 2014-10-29 | PMID:26420866 | |
GO.xxxxx | 5E7Q | Acyl-CoA synthetase PtmA2 from Streptomyces platensis |
2015-10-12 | 2015-10-21 | ||
GO.xxxxx | 5F1P | Crystal Structure of Dehydrogenase from Streptomyces platensis |
2015-11-30 | 2015-12-30 | ||
GO.119842 | 5F4Z | The crystal structure of an epoxide hydrolase from Streptomyces carzinostaticus subsp. neocarzinostaticus |
2015-12-03 | 2016-02-17 | ||
GO.xxxxx | 5HOQ | Apo structure of CalS11, TDP-rhamnose 3 -o-methyltransferase, an enzyme in Calicheamicin biosynthesis |
2016-01-19 | 2016-03-30 | PMID:26958582 | |
GO.xxxxx | 4WS9 | Crystal structure of sMAT N159G from Sulfolobus solfataricus |
2014-10-26 | 2014-11-05 | ||
GO.xxxxx | 5EEG | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with tetrazole-SAH |
2015-10-22 | 2015-12-23 | PMID:27351335 | |
GO.xxxxx | 5EEH | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 2-chloro-4-nitrophenol |
2015-10-22 | 2015-12-16 | PMID:27351335 | |
GO.128526 | 5DU2 | Structural analysis of EspG2 glycosyltransferase |
2015-09-18 | 2015-10-14 | ||
GO.131339 | 5INJ | Crystal Structure of Prenyltransferase PriB Ternary Complex with L-Tryptophan and Dimethylallyl thiolodiphosphate (DMSPP) |
2016-03-07 | 2016-05-11 | ||
GO.xxxxx | 5JR3 | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferone |
2016-05-05 | 2016-06-01 | ||
GO.131339 | 5JXM | Crystal Structure of Prenyltransferase PriB Apo Form |
2016-05-13 | 2016-06-08 | ||
GO.xxxxx | 5K9M | Crystal Structure of PriB Binary Complex with Product Diphosphate |
2016-06-01 | 2016-06-15 | ||
GO.111111 | 5CQF | Crystal structure of L-lysine 6-monooxygenase from Pseudomonas syringae |
2015-07-21 | 2015-09-30 | ||
GO.xxxxx | 5D6W | Crystal structure of double tudor domain of human lysine demethylase KDM4A |
2015-08-13 | 2015-11-25 | PMID:27841353 | |
GO.xxxxx | 5D6X | Crystal structure of double tudor domain of human lysine demethylase KDM4A |
2015-08-13 | 2015-11-25 | PMID:27841353 | |
GO.xxxxx | 5D6Y | Crystal structure of double tudor domain of human lysine demethylase KDM4A complexed with histone H3K23me3 |
2015-08-13 | 2016-02-10 | PMID:27841353 |
Chang A, Singh S, Helmich KE, Goff RD, Bingman CA, Thorson JS, Phillips GN Jr. Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17649-54. doi: 10.1073/pnas.1108484108. PubMed PMID: 21987796; PMCID: PMC3203770. PDB ID: 3RSC 3OTI 3OTH 3OTG 3IAA 3IA7.
Chang A, Singh S, Phillips GN Jr, Thorson JS. Glycotransferase structural biology and its role in the design of catalysts for glycosylation. Current Opinion in Biotechnology. 2011 22:800-808 PubMed PMID: 21592771; PMCID: PMC3163058.
Bitto E, Kim DJ, Bingman CA, Kim HJ, Han BW, Phillips GN Jr. Crystal structure of tandem ACT domain-containing protein ACTP from Galdieria sulphuraria. Proteins. 2012 Aug; 80(8):2105-9. doi: 10.1002/prot.24101. PubMed PMID: 22528523; PMCID: PMC4226431. PDB ID: 2NYI.
Singh S, Phillips GN Jr, Thorson JS. The structural biology of enzymes involved in natural product glycosylation. Nat Prod Rep. 2012 Oct; 29(10):1201-37. doi: 10.1039/c2np20039b. Review. PubMed PMID: 22688446; PMCID: PMC3627186.
Lohman JR, Bingman CA, Phillips GN Jr, Shen B. Structure of the bifunctional acyltransferase/decarboxylase LnmK from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold. Biochemistry. 2013 Feb 5; 52(5):902-11. doi: 10.1021/bi301652y. PubMed PMID: 23320975; PMCID: PMC3567400. PDB ID: 4HZP 4HZO 4HZN.
Wang F, Zhou M, Singh S, Yennamalli RM, Bingman CA, Thorson JS, Phillips GN Jr. Crystal structure of SsfS6, the putative C-glycosyltransferase involved in SF2575 biosynthesis. Proteins. 2013 Jul; 81(7):1277-82. doi: 10.1002/prot.24289. PubMed PMID: 23526584; PMCID: PMC3896073. PDB ID: 4G2T 4FZR.
Desai KK, Bingman CA, Phillips GN Jr, Raines RT. Structures of the noncanonical RNA ligase RtcB reveal the mechanism of histidine guanylylation. Biochemistry. 2013 Apr 16;52(15):2518-25. doi: 10.1021/bi4002375. PubMed PMID: 23560983; PMCID: PMC3670941. PDB ID: 4ISZ 4IT0 4ISJ.
Singh S, Chang A, Helmich KE, Bingman CA, Wrobel RL, Beebe ET, Makino S, Aceti DJ, Dyer K, Hura GL, Sunkara M, Morris AJ, Phillips GN Jr, Thorson JS. Structural and functional characterization of CalS11, a TDP-rhamnose 3'-O-methyltransferase involved in calicheamicin biosynthesis. ACS Chem Biol. 2013 Jul 19;8(7):1632-9. doi: 10.1021/cb400068k. PubMed PMID: 23662776; PMCID: PMC3875630 PDB ID: 3TOS 4GF5.
Desai KK, Cheng CL, Bingman CA, Phillips GN Jr, Raines RT. A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation. Nucleic Acids Res. 2014 Apr;42(6):3931-42. doi: 10.1093/nar/gkt1375. PubMed PMID: 24435797; PMCID: PMC3973293. PDB ID: 4N2P.
Singh S, Zhang J, Huber TD, Sunkara M, Hurley K, Goff RD, Wang G, Zhang W, Liu C, Rohr J, Van Lanen SG, Morris AJ, Thorson JS. Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-(L)-methionine analogues. Angew Chem Int Ed Engl. 2014 Apr 7;53(15):3965-9. doi: 10.1002/anie.201308272. PubMed PMID: 24616228; PMCID: PMC4076696.
Wang F, Singh S, Zhang J, Huber TD, Helmich KE, Sunkara M, Hurley KA, Goff RD, Bingman CA, Morris AJ, Thorson JS, Phillips GN Jr. Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus. FEBS J. 2014 Sep;281(18):4224-39. doi: 10.1111/febs.12784. PubMed PMID: 24649856; PMCID: PMC4169312. PDB ID: 4L7I 4L2Z 4K0B 4HPV.
Yennamalli R, Arangarasan R, Bryden A, Gleicher M, Phillips GN Jr. Using a commodity high-definition television for collaborative structural biology. J Appl Crystallogr. 2014 May 29;47(Pt 3):1153-1157. PubMed PMID: 24904249; PMCID: PMC4038803.
Lohman JR, Ma M, Cuff ME, Bigelow L, Bearden J, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B. The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins. Proteins. 2014 Jul;82(7):1210-8. PubMed PMID: 25050442; PMCID: PMC4109001. PDB ID: 4NEO.
Elshahawi SI, Ramelot TA, Seetharaman J, Chen J, Singh S, Yang Y, Pederson K, Kharel MK, Xiao R, Lew S, Yennamalli RM, Miller MD, Wang F, Tong L, Montelione GT, Kennedy MA, Bingman CA, Zhu H, Phillips GN Jr, Thorson JS. Structure-guided functional characterization of enediyne self-sacrifice resistance proteins, CalU16 and CalU19. ACS Chem Biol. 2014 Oct 17;9(10):2347-58. doi: 10.1021/cb500327m. PubMed PMID: 25079510; PMCID: PMC4201346. PDB ID: 4FPW 2LUZ.
Cao H, Walton JD, Brumm P, Phillips GN Jr. Structure and substrate specificity of a eukaryotic fucosidase from Fusarium graminearum. J Biol Chem. 2014 Sep 12;289(37):25624-38. doi: 10.1074/jbc.M114.583286. PubMed PMID: 25086049; PMCID: PMC4162167. PDB ID: 4PSR 4PSP 4NI3.
Desai KK, Bingman CA, Cheng CL, Phillips GN Jr, Raines RT. Structure of RNA 3'-phosphate cyclase bound to substrate RNA. RNA. 2014 Oct;20(10):1560-6. doi: 10.1261/rna.045823.114. PubMed PMID: 25161314; PMCID: PMC4174438. PDB ID: 4O8J 4O89.
Book AJ, Yennamalli RM, Takasuka TE, Currie CR, Phillips GN Jr, Fox BG. Evolution of substrate specificity in bacterial AA10 lytic polysaccharide monooxygenases. Biotechnol Biofuels. 2014 Aug 6;7:109. doi: 10.1186/1754-6834-7-109. PubMed PMID: 25161697; PMCID: PMC4144037.
Weerth RS, Michalska K, Bingman CA, Yennamalli RM, Li H, Jedrzejczak R, Wang F, Babnigg G, Joachimiak A, Thomas MG, Phillips GN Jr. Structure of a cupin protein Plu4264 from Photorhabdus luminescens subsp. laumondii TTO1 at 1.35 Å resolution. Proteins. 2015 Feb;83(2):383-8. doi: 10.1002/prot.24705. PubMed PMID: 25354690; PMCID: PMC4300268. PDB ID: 4Q29 4MV2.
Park MS, Bitto E, Kim KR, Bingman CA, Miller MD, Kim HJ, Han BW, Phillips GN Jr. Crystal structure of human protein N-terminal glutamine amidohydrolase, an initial component of the N-end rule pathway. PLoS One. 2014 Oct 30;9(10):e111142. doi: 10.1371/journal.pone.0111142. PubMed PMID: 25356641; PMCID: PMC4214742. PDB ID: 4W79.
Kim do J, Bitto E, Bingman CA, Kim HJ, Han BW, Phillips GN Jr. Crystal structure of the protein At3g01520, a eukaryotic universal stress protein-like protein from Arabidopsis thaliana in complex with AMP. Proteins. 2015 Jul;83(7):1368-73. doi: 10.1002/prot.24821. PubMed PMID: 25921306; PMCID: PMC4624624. PDB ID: 2GM3.
Wang F, Singh S, Xu W, Helmich KE, Miller MD, Cao H, Bingman CA, Thorson JS, Phillips GN Jr. Structural Basis for the Stereochemical Control of Amine Installation in Nucleotide Sugar Aminotransferases. ACS Chem Biol. 2015 Sep 18;10(9):2048-56. doi: 10.1021/acschembio.5b00244. PubMed PMID: 26023720; PMCID: PMC4575645. PDB ID: 4ZAH.
Singh S, Kim Y, Wang F, Bigelow L, Endres M, Kharel MK, Babnigg G, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Jr. Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis. Proteins. 2015 Aug;83(8):1547-54. doi: 10.1002/prot.24844. PubMed PMID: 26061967; PMCID: PMC4570032. PDB ID: 4XAU 4ZWV.
Samuel PP, Smith LP, Phillips GN Jr, Olson JS. Apoglobin Stability Is the Major Factor Governing both Cell-free and in Vivo Expression of Holomyoglobin. J Biol Chem. 2015 Sep 25;290(39):23479-95. doi: 10.1074/jbc.M115.672204. PubMed PMID: 26205820; PMCID: PMC4583012.
Singh S, Michalska K, Bigelow L, Endres M, Kharel MK, Babnigg G, Yennamalli RM, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Jr. Structural Characterization of CalS8, a TDP-α-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis. J Biol Chem. 2015 Oct 23;290(43):26249-58. doi: 10.1074/jbc.M115.673459. PubMed PMID: 26240141; PMCID: PMC4646273. PDB ID: 4XRR. 4XR9.
Lohman JR, Ma M, Osipiuk J, Nocek B, Kim Y, Chang C, Cuff M, Mack J, Bigelow L, Li H, Endres M, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B. Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12693-8. doi: 10.1073/pnas.1515460112. PubMed PMID: 26420866; PMCID: PMC4611616. PDB ID: 4ZDN 4WKY 4QYR 4TKT 4OQJ 4OPF 4OPE.
Rudolf JD, Bigelow L, Chang C, Cuff ME, Lohman JR, Chang CY, Ma M, Yang D, Clancy S, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B. Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892. Biochemistry. 2015 Nov 17;54(45):6842-51. doi: 10.1021/acs.biochem.5b01008. PubMed PMID: 26512730; PMCID: PMC4809751. PDB ID: 5CJ3 4IAG.
Helmich KE, Pereira JH, Gall DL, Heins RA, McAndrew RP, Bingman C, Deng K, Holland KC, Noguera DR, Simmons BA, Sale KL, Ralph J, Donohue TJ, Adams PD, Phillips GN Jr. Structural Basis of Stereospecificity in the Bacterial Enzymatic Cleavage of β-Aryl Ether Bonds in Lignin. J Biol Chem. 2016 Mar 4;291(10):5234-46. doi: 10.1074/jbc.M115.694307. PubMed PMID: 26637355; PMCID: PMC4777856. PDB ID: 4XT0 4YAN 4YAM.
Han L, Singh S, Thorson JS, Phillips GN Jr. Loop dynamics of thymidine diphosphate-rhamnose 3'-O-methyltransferase (CalS11), an enzyme in calicheamicin biosynthesis. Struct Dyn. 2016 Feb 18;3(1):012004. doi: 10.1063/1.4941368. PubMed PMID: 26958582; PMCID: PMC4760980. PDB ID: 5HOQ.
Cao H, Tan K, Wang F, Bigelow L, Yennamalli RM, Jedrzejczak R, Babnigg G, Bingman CA, Joachimiak A, Kharel MK, Singh S, Thorson JS, Phillips GN Jr. Structural dynamics of a methionine γ-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate. Struct Dyn. 2016 Apr 29;3(3):034702. doi: 10.1063/1.4948539. PubMed PMID: 27191010; PMCID: PMC4851618. PDB ID: 4Q31.
Huber TD, Wang F, Singh S, Johnson BR, Zhang J, Sunkara M, Van Lanen SG, Morris AJ, Phillips GN Jr, Thorson JS. Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways. ACS Chem Biol. 2016 Sep 16;11(9):2484-91. doi: 10.1021/acschembio.6b00348. PubMed PMID: 27351335; PMCID: PMC5026608. PDB ID: 5EEG 5EEH.
Rudolf JD, Dong LB, Cao H, Hatzos-Skintges C, Osipiuk J, Endres M, Chang CY, Ma M, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B. Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase. J Am Chem Soc. 2016 Aug 31;138(34):10905-15. doi: 10.1021/jacs.6b04317. PubMed PMID: 27490479; PMCID: PMC5013971. PDB ID: 5BP8.
Chang CY, Lohman JR, Cao H, Tan K, Rudolf JD, Ma M, Xu W, Bingman CA, Yennamalli RM, Bigelow L, Babnigg G, Yan X, Joachimiak A, Phillips GN Jr, Shen B. Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus. Biochemistry. 2016 Sep 13;55(36):5142-54. doi: 10.1021/acs.biochem.6b00713. PubMed PMID: 27560143; PMCID: PMC5024704. PDB ID: 4R82 4OO2 4HX6
Huang T, Chang CY, Lohman JR, Rudolf JD, Kim Y, Chang C, Yang D, Ma M, Yan X, Crnovcic I, Bigelow L, Clancy S, Bingman CA, Yennamalli RM, Babnigg G, Joachimiak A, Phillips GN, Shen B. Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027. J Antibiot (Tokyo). 2016 Oct;69(10):731-740. doi: 10.1038/ja.2016.88. PubMed PMID: 27406907; PMCID: PMC5083130. PDB ID: 4OVM 4I4K.
Lee K, Sharma R, Shrestha OK, Bingman CA, Craig EA. Dual interaction of the Hsp70 J-protein cochaperone Zuotin with the 40S and 60S ribosomal subunits. Nat Struct Mol Biol. 2016 Nov;23(11):1003-1010. doi: 10.1038/nsmb.3299. PubMed PMID: 27669034; PMCID: PMC5097012. PDB ID: 5DJE.
Su Z, Wang F, Lee JH, Stephens KE, Papazyan R, Voronina E, Krautkramer KA, Raman A, Thorpe JJ, Boersma MD, Kuznetsov VI, Miller MD, Taverna SD, Phillips GN Jr, Denu JM. Reader domain specificity and lysine demethylase-4 family function. Nat Commun. 2016 Nov 14;7:13387. doi: 10.1038/ncomms13387. PubMed PMID: 27841353; PMCID: PMC5114558. PDB ID: 5D6Y 5D6X 5D6W.
Kupitz C, Olmos JL Jr, Holl M, Tremblay L, Pande K, Pandey S, Oberthür D, Hunter M, Liang M, Aquila A, Tenboer J, Calvey G, Katz A, Chen Y, Wiedorn MO, Knoska J, Meents A, Majriani V, Norwood T, Poudyal I, Grant T, Miller MD, Xu W, Tolstikova A, Morgan A, Metz M, Martin-Garcia JM, Zook JD, Roy-Chowdhury S, Coe J, Nagaratnam N, Meza D, Fromme R, Basu S, Frank M, White T, Barty A, Bajt S, Yefanov O, Chapman HN, Zatsepin N, Nelson G, Weierstall U, Spence J, Schwander P, Pollack L, Fromme P, Ourmazd A, Phillips GN Jr, Schmidt M. Structural enzymology using X-ray free electron lasers. Struct Dyn. 2016 Dec 15;4(4):044003. doi: 10.1063/1.4972069. PubMed PMID: 28083542; PMCID: PMC5178802.
Hughes RR, Shaaban KA, Zhang J, Cao H, Phillips GN Jr, Thorson JS. OleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation.Chembiochem. 2017 Jan 9. [Epub ahead of print] doi: 10.1002/cbic.201600676 . PubMed PMID: 28067448;